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XRC Laboratory Supervisor Dr. Paul Swartz Phone: 919.513.0173 Fax: 919.515.2047 paul_swartz@ncsu.edu |
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Principal
Investigator Dr. Robert B. Rose Phone: 919.513.4191 Office Location: Polk Hall 132 bob_rose@ncsu.edu |
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Principal
Investigator Dr. Flora Meilleur Phone: 865.576.2779 Office Location: Polk Hall 148 meilleurf@ornl.gov |
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Principal
Investigator Dr. Clay Clark Phone: 919.515.5805 Office Location: Polk Hall 140 clay_clark@ncsu.edu |
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Lab Location: Rooms 01 - 05 Polk Hall |
Mailing Address:128 Polk Hall North Carolina State University Raleigh, NC 27650-7622 |
Biological X-ray Crystallography
Macromolecular x-ray crystallography is a means of determining the 3-dimensional structure of a macro-molecule from the systematic scattering of x-rays by a crystal made of that macro-molecule. Bio-macromolecules include protein, DNA, RNA, and combinations of the three. Purified biological molecules are used to grow a crystal that is then collected and prepared for analysis. The crystal is positioned in the x-ray beam and diffracted x-rays are detected using an image plate detector. Data analysis and processing followed by modeling of the data yield the 3-dimensional structure. The 3-dimensional structure of the macro-molecule is used to study the details of the relationship between the structure of the biological macro-molecule and its function. Additionally, the 3-dimensional models of macromolecules are used in the intelligent design of pharmaceuticals and pesticides as well as to understand the nature of metabolic diseases. |
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