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Resources
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Our Research |
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Detailed descriptions of
our research. A brief description of our research is located
just to your right |
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Publications |
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A list of our selected publications
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Lab Pictures |
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Pictures of staff and students as well as
laboratory layout and instrumentation |
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Useful Links
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Some useful and not so useful links |
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Dr. Michael B. Goshe |
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Undergraduate Advising |
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By
Appointment only |
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Collaborations: |
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Always interested in new areas of research - email
us!
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Area 1 - Functional Proteomics |
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Wang, X., Goshe, M. B., Soderblom,
E. J., Phinney, B. S., Kuchar, J. A., Li, J., Asami, T.,
Yoshida, S., Huber, S. C., Clouse, S. D. (2005)
Identification and Functional Analysis of in Vivo
Phosphorylation Sites of the Arabidopsis
BRASSINOSTEROID-INSENSITIVE1 Receptor Kinase. Plant
Cell. 2005 Jun;17(6):1685-703
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Soderblom, E. J., Cawthon, D.,
Duhart, H., Xu, Z. A., Slikker Jr., W., and Ali, S. F.,
and Goshe, M. B. (2005) An Improved Labeling Method
using Phosphoprotein Isotope-coded Solid-phase Tags for
Neuronal Cell Applications. Int J Neuroprotec
Neuroregen 1(2), 91-97.
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Cawthon D., Soderblom, E. J., Xu,
Z. A., Duhart, H., Slikker Jr., W., and Ali, S. F.,
and Goshe, M. B. (2005) Quantitative Analysis of
Phosphoproteins in a Parkinson's Disease Model using
Phosphoprotein Isotope-coded Solid-phase Tags. Int
J Neuroprotec Neuroregen 1(2), 98-106.
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Qian, W-J., Goshe, M. B., Camp, D.
G., Yu, L-R., Tang, K., and Smith, R.D. (2003).
Phosphoprotein Isotope-coded Solid-phase Tag Approach
for Enrichment and Quantitative Analysis of
Phosphopeptides from Complex Mixtures. Anal. Chem.
75, 5441-5450.
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Goshe, M. B. and Smith, R.
D. Stable Isotope-coded Proteomic Mass Spectrometry.
(2003) Curr. Opin. Biotechnol. 14, 101-109.
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Goshe, M. B., Conrads, T. P.,
Panisko, E. A., Angell, N.H., Veenstra, T.D., and Smith.
R. D. (2001). Phosphoprotein Isotope-Coded Affinity Tag
Approach for Isolating and Quantitating Phosphopeptides
in Proteome-Wide Analyses. Anal. Chem. 73,
2578-2586.
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Area 2 - Expressional Proteomics |
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Liu,
H.C., Soderblom, E.J., Goshe, M.B.(2006) A mass
spectrometry-based proteomic approach to study Marek's
Disease Virus gene expression. J. Virol Methods. 135,
66-75.
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Blonder, J., Goshe, M. B.,
Xiao, W., Camp II, D. G., Wingerd, M., Davis, R. W.,
and Smith, R. D. (2004). Global Analysis of the
Membrane Subproteome of Pseudomonas aeruginosa
Using Liquid Chromatography-Tandem Mass
Spectrometry. J. Proteome Res. 3,
434-444.
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Belov, M. E. ,Rakov,
V. S., Nikolaev, E. N., Goshe, M. B., Anderson, G.
A., and Smith, R. D. (2003). Initial Implementation
of External Accumulation Liquid Chromatography/
Electrospray Ionization Fourier Transform Ion
Cyclotron Resonance with Automated Gain Control.
Rapid Commun. Mass Spectrom. 17, 627–636.
- Goshe, M. B., Blonder, J.,
and Smith, R. D. (2003). Affinity Labeling of Highly
Hydrophobic Integral Membrane Proteins for
Proteome-Wide Analysis. J. Proteome Res.
2, 153-161.
- Blonder,
J., Goshe, M. B., Moore, R. J., Pasa-Tolic, L.,
Masselon, C. D., Lipton, M. S., and Smith, R. D.
(2002). A Method for the Enrichment of Integral
Membrane Proteins for Proteomic Analysis Using
Liquid Chromatography-Tandem Mass Spectrometry.
J. Proteome Res. 1, 351-360.
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Area 3 - Structural mass
spectrometry |
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Soderblom, E. J., and Goshe, M.
B. (2006) Collision-induced dissociative chemical
cross-linking reagents and methodology: applications
to protein structural characterization using tandem
mass spectrometry analysis. Anal Chem 78,
8059-8068
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Bobay, B. G., Benson, L., Naylor,
S., Feeney, B., Clark, A. C., Goshe, M. B., Strauch,
M. A., Thompson, R., and Cavanagh, J. (2004)
Evaluation of the DNA Binding Tendencies of the
Transition State Regulator AbrB. Biochemistry
43, 16106-16118.
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Ramelot, T. A., Cort, J. R.,
Yee, A. A., Liu, F., Goshe, M. B., Edwards, A. M.,
Smith, R. D., Arrowsmith C. H., Dever, T. E., and
Kennedy, M. A. (2002). Myxoma Virus Immunomodulatory
Protein M156R is a Structural Mimic of Eukaryotic
Translation Initiation Factor eIF2a.
J. Mol. Biol. 322, 943-954.
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Nukuna, B. N., Goshe, M. B., and
Anderson, V. E. (2001). Sites of Hydroxyl Radical
Reaction with Amino Acids Identified by 2H
NMR Detection of Induced 1H/2H
Exchange. J. Am. Chem. Soc. 123, 1208-1214.
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Goshe, M. B., Chen, Y. H., and
Anderson, V. E. (2000). Identification of the Sites of
Hydroxyl Radical Reaction with Peptides by
Hydrogen/Deuterium Exchange: Prevalence of Reactions
with the Side Chains. Biochemistry 39,
1761-1770.
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