Selected Publications

Tang, G. and Maxwell, E.S. (2008) "Xenopus microRNA genes are predominantly located within introns and are differentially expressed in adult frog tissues via post-transcriptional regulation", Genome Research, 18: 104-112.

Gagnon, K., Zhang, X., and Maxwell, E.S. (2008) "The box C/D RNPs: evolutionarily ancient nucleotide modification complexes", in Frontiers in RNA and DNA Editing, H. Smith editor, John Wiley and Sons, in press.

Grossjean, H., Gupta, R., and Maxwell, E.S. (2008) "Modified nucleotides in Archaea", in Archaea, P. Blum editor, Horizon Press, in press.

Appel, D. and Maxwell, E.S. (2007) "Structural features of the guide:target RNA duplex required for Archaeal box C/D sRNA-guided nucleotide 2'-O-methylation", RNA, 13: 899-911.

Gagnon, K., Zhang, X., and Maxwell, E.S. (2007) "In vitro reconstitution and affinity purification of catalytically active Archaeal box C/D sRNP complexes", RNA Modification in Methods in Enzymology, 425: 263-282.

Gagnon, K, Zhang, X., Agris, P., and Maxwell, E.S. (2006) " Assembly of the Archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling", J. Mol. Biol., 362: 1025-1042.

Zhang, X., Champion, E., Tran, E., Brown, B., Baserga, S., and Maxwell, E.S. (2006) "The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation", RNA, 12: 1-12.

Suryadi, J., Tran, E., Maxwell, E.S., and Brown, B. (2005) "The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs", Biochemistry, 44 (28): 9657-9672.

Tran, E., Zhang, X., Lackey, L., and Maxwell, E.S. (2005) "Conserved Spacing Between the Box C/D and C'/D' RNPs of Archaeal Box C/D sRNAs is required for Efficient 2'-O-Methylation of Targeted RNA Nucleotides", RNA, 11: 285-293.

Sanjay K.S. , Singh S.K. , Gurha P., Tran E.J., Maxwell E.S., Gupta R. (2004) " Sequential 2 '-O-methylation of archaeal pre-tRNA(Trp) nucleotides is guided by the intron-encoded but trans-acting box c/D ribonucleoprotein of pre-tRNA ", J. Biol. Chem., 279(46): 47661-47671.

Tran E., Brown J., Maxwell E.S. (2004) "Evolutionary origins of the RNA-guided nucleotide-modification complexes: from the primitive translation apparatus?", Trends in Biochemical Sciences, 29 (7): 343-350.

Elizabeth J. Tran, Xinxin Zhang, E. Stuart Maxwell (2003) "Efficient ribonucleotide methylation requires juxtaposed and symmetrically assembled Archaeal Box C/D and C'/D' RNPs", EMBO J., 22(15): 3930-3940.

Kuhn, J., Tran, E., and Maxwell, E.S. (2002) "Archaeal Ribosomal Protein L7 Is a Functional Homolog of the Eukaryotic 15.5kD/Snu13p snoRNP Core Protein", Nucleic Acids Res., 30: 931-941.

King, T., Decatur, W., Bertrand, E., Maxwell, E.S., and Fournier, M.J. (2001) "A Well-Connected and Conserved Nucleoplasmic Helicase Is Required for the Production of Box C/D and H/ACA snoRNAs and Localization of snoRNP Proteins", Mol. Cell. Biol., 21: 7731-7746 [Abstract].

Newman, D., Kuhn, J., Shanab, G., and Maxwell, E.S. (2000) "Box C/D snoRNA-Associated Proteins: Two Pairs of Evolutionarily Ancient Proteins and a Possible Link to RNA Transcription", RNA, 6:861-879 [Abstract].

Lange, T.S., Borovjagin, A., Maxwell, E.S., and Gerbi, S.A. (1998) "Conserved boxes C and D are essential nucleolar localization elements of U14 and U8 snoRNAs", EMBO J., 17:3176-3187.

Watkins, N.J., Newman, D.R., Kuhn, J.F., and Maxwell, E.S. (1998) "In vitro assembly of the mouse U14 snoRNP core complex and identification of a 65-kDa box C/D-binding protein", RNA, 4: 582-593 [Abstract].

Xia, L., Watkins, N., and Maxwell, E.S. (1997) "Identification of Specific Nucleotide Sequences and Structural Elements Required for Intronic U14 snoRNA Processing", RNA, 3: 17-26 [Abstract].

Enright, C.A., Maxwell, E.S., and Sollner-Webb, B. (1996) "5' ETS rRNA Processing Facilitated by Four Small RNAs: U14, E3, U17, and U3", RNA, 2: 1094-1099 [Abstract].

Watkins, N., Leverette, R., Xia, L., Andrews, M., and Maxwell, E.S. (1996) "Elements Essential for Processing Intronic U14 snoRNA Are Located at the Termini of the Mature snoRNA Sequence and Include Conserved Nucleotide Boxes C and D", RNA, 2: 118-133 [Abstract].

Xia, L., Liu, J., Sage, C., Trexler, E.B., Andrews, M., and Maxwell, E.S. (1995) "Intronic U14 snoRNAs of Xenopus laevis are Located in Two Different Parent Genes and Can Be Processed from Their Introns During Early Oogenesis", Nucleic Acids Res., 23: 4844-4849 [Abstract].

Maxwell, E.S. and Fournier, M.J. (1995) "The Small Nucleolar RNAs", Annual Reviews of Biochemistry, 35: 897-934 [Abstract].

Barbhaiya, H., Leverette, R., and Maxwell, E. S. (1994) "Mouse U14 snRNAs are Processed from Three Separate Introns of the Cognate Heat Shock 70 Pre-messenger RNA", Eur. J. Biochem., 226: 765-771 [Abstract].

Fournier, M. J. and Maxwell, E. S. (1993) "Nucleolar snRNAs: Catching Up With the Spliceosomal snRNAs", Trends in Biochemical Sciences, 18: 131-135 [Abstract].

Leverette, R., Andrews, M., and Maxwell, E.S. (1992) "Mouse U14 snRNA is a Processed Intron of the Mouse Cognate hsc70 Heat Shock Pre-messenger RNA", Cell, 71: 1215-1221 [Abstract].