Robert B. Rose, Assistant Professor
Department of Molecular and Structural Biochemistry
North Carolina State University

Yale College, New Haven, CT. B.A. 1982 Physics.
University of California, Berkeley, CA. M.A. 1989 History of Science.
University of California, San Francisco, CA. Ph.D. 1996 Bipohysics.

1996-2001 Postdoctoral Research Fellow, Department of Molecular and Cell Biology, University of California, Berkeley, California.
2001-2002 Visiting Scientist, Department of Molecular and Cell Biology, University of California, Berkeley, California.
2002-present Assistant Professor, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina.

1989-1991 National Institute of Health Biophysics Training Grant, University of California, San Francisco.
1996-1999 National Institute of Health, National Research Service Award, University of California, Berkeley.
1999-2001 Juvenile Diabetes Foundation Postdoctoral Fellowship, University of California, Berkeley.
2003-2006 American Diabetes Association Junior Faculty Award, North Carolina State University.
2005-2206 Faculty Research and Professional Development Award, North Carolina State University.
2007-2012 National Science Foundation CAREER Award, North Carolina State University.

1. Leavitt A.D., Rose R.B., Varmus H.E. 1992. Both substrate and target oligonucleotide sequences affect integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. J Virol, 66:2359-68.

2. Rose, R. B., Rosé, J. R., Salto, R., Craik, C. S., Stroud, R. M. 1993. Structure of the protease from Simian Immunodeficeincy Virus: complex with an irreversible nonpeptide inhibitor. Biochemistry 32:12498-507.

3. Rose, R. B., Craik, C. S., Douglas, N. L., Stroud, R. M. 1996. Three-di me nsional structures of HIV-1 and SIV protease product complexes. Biochemistry 35:12933-44.

4. Rose, R. B., Craik C. S., Stroud, R.M.1998. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry 37:2607-21.

5. Rose, R. B., Bayle, J. H., Endrizzi, J. A., Cronk, J. D., Crabtree, G. R., Alber, T. 2000. Structural basis of di me rization, coactivator recognition and MODY3 mutations in HNF-1 a . Nature Struct. Biol. 7:744-748.

6. Rose, R. B., Endrizzi, J. A., Cronk, J. D., Holton, J., Alber, T. 2000. High-resolution structure of the HNF-1 a di me rization domain. Biochemistry 39:15062-15070.

7. Faccioti, M. T., Rouhani, S., Burkard, F. T., Betancourt, F. M., Downing, K. H., Rose, R. B., McDermott, G., Glaeser, R. M. 2001. Structre of an early inter me diate in the M-state phase of the bacteriorhodopsin photocycle. Biophysical J. 81 :3442-3455.

8. Rose, R. B., Pullen, K. E., Bayle, J. H., Crabtree, G. R., and Alber, T. 2004. Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Biochemistry 43, 7345-55.

9. Wan C., Tempel W., Liu X.J., Wang B.C., Rose R.B. 2005. Structure of the conserved transcriptional repressor enhancer of rudi me ntary homolog. Biochemistry . 44:5017-23.

10. Longo A., Guanga G., Rose R.B. 2007. Structural basis for induced fit mechanisms in DNA recognition by the Pdx1 homeodomain. Biochemistry 46:2948-2957 .

11. Longo A., Guanga G., Rose, R.B. Crystal structure of an E47-NeuroD1 basic-helix-loop-helix-DNA complex: heterodimer selectivity and DNA recognition(submitted)