Department of Biochemistry
North Carolina State University
128 Polk Hall
Raleigh, NC 27695-7622
phone: (919) 513-4191
e-mail: bob_rose@ncsu.edu

Rose Lab

Robert Rose, Assistant Professor

Home Rose Research People Publications Teaching Links

Publications

1. Leavitt A.D., Rose R.B., Varmus H.E. 1992. Both substrate and target oligonucleotide sequences affect integration mediated by human immunodeficiency virus type 1 integrase protein produced in Saccharomyces cerevisiae. J Virol, 66:2359-68.

2. Rose, R. B., Rosé, J. R., Salto, R., Craik, C. S., Stroud, R. M. 1993. Structure of the protease from Simian Immunodeficeincy Virus: complex with an irreversible nonpeptide inhibitor. Biochemistry 32:12498-507.

3. Rose, R. B., Craik, C. S., Douglas, N. L., Stroud, R. M. 1996. Three-di me nsional structures of HIV-1 and SIV protease product complexes. Biochemistry 35:12933-44.

4. Rose, R. B., Craik C. S., Stroud, R.M.1998. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry 37:2607-21.

5. Rose, R. B., Bayle, J. H., Endrizzi, J. A., Cronk, J. D., Crabtree, G. R., Alber, T. 2000. Structural basis of di me rization, coactivator recognition and MODY3 mutations in HNF-1 a . Nature Struct. Biol. 7:744-748.

6. Rose, R. B., Endrizzi, J. A., Cronk, J. D., Holton, J., Alber, T. 2000. High-resolution structure of the HNF-1 a di me rization domain. Biochemistry 39:15062-15070.

7. Faccioti, M. T., Rouhani, S., Burkard, F. T., Betancourt, F. M., Downing, K. H., Rose, R. B., McDermott, G., Glaeser, R. M. 2001. Structre of an early inter me diate in the M-state phase of the bacteriorhodopsin photocycle. Biophysical J. 81 :3442-3455.

8. Rose, R. B., Pullen, K. E., Bayle, J. H., Crabtree, G. R., and Alber, T. 2004. Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Biochemistry 43, 7345-55.

9. Wan C., Tempel W., Liu X.J., Wang B.C., Rose R.B. 2005. Structure of the conserved transcriptional repressor enhancer of rudi me ntary homolog. Biochemistry . 44:5017-23.

10. Longo A., Guanga G., Rose R.B. 2007. Structural basis for induced fit mechanisms in DNA recognition by the Pdx1 homeodomain. Biochemistry 46:2948-2957 .

11. Longo A., Guanga G., Rose, R.B. Crystal structure of an E47-NeuroD1 basic-helix-loop-helix-DNA complex: heterodimer selectivity and DNA recognition (submitted)