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NC State Biochemistry



Publication by Dr. Brown chosen as Highlighted Article in Virology

The editors of Virology have chosen a recent publication by Dr. Dennis Brown to be highlighted on the front page of the Virology website under the section "Highlighted Articles." The paper, titled "Flavivirus infection from mosquitoes in vitro reveals cell entry at the plasma membrane", was considered to be of special interest to the readers of the journal.

In this study, Dr. Ricardo Vancini, a post-doctoral associate with Drs. Brown and Raquel Hernandez, examined the early events in the infection of host cells by flaviviruses by means of electron microscopy and immuno-gold labeling of viral particles during cell entry, and used as a new approach for infecting cells with viruses obtained directly from mosquitoes. The results show that Dengue and West Nile viruses may infect cells by a mechanism that involves direct penetration of the host cell plasma membrane as proposed for alphaviruses.

To access the full article, visit the journal website here.