NC State Biochemistry receives state and federal revenues, but these sources represent a fraction of the support required to maintain successful programs and facilities. Your donations will make the difference for our faculty and students to meet the global challenges of 21st Century:

- Enhancing the production, quality, accessibility and proftability of food, plant, animal and bioenergy products for North   Carolina, the nation and the world
- Ensuring environmental stewardship and sustainability of air, land, soil and water resources
- Creating a food supply that is safe, secure, healthy, affordable and of high quality
- Improving human health and well-being for individuals, families and communities and
- Preparing students and stakeholders for leadership and success in the global workforce.

NC State Biochemistry



Paul Swartz XRC Laboratory Supervisor
Dr. Paul Swartz
Phone: 919.513.0173
Fax: 919.515.2047

Robert Rose Principal Investigator
Dr. Robert B. Rose
Phone: 919.513.4191
Office Location: Polk Hall 132

 Flora Meilleur Principal Investigator
Dr. Flora Meilleur
Phone: 865.576.2779
Office Location: Polk Hall 148

Clay Clark Principal Investigator
Dr. Guozhou Xu
Phone: 919.515.0835
Office Location: Polk Hall

Lab Location: Rooms 01 - 05 Polk Hall
Corner of Stinson Dr. and W. Broughton Dr.
North Carolina State University

Mailing Address:128 Polk Hall
North Carolina State University
Raleigh, NC 27650-7622

Biological X-ray Crystallography

Macromolecular x-ray crystallography is a means of determining the 3-dimensional structure of a macro-molecule from the systematic scattering of x-rays by a crystal made of that macro-molecule. Bio-macromolecules include protein, DNA, RNA, and combinations of the three. Purified biological molecules are used to grow a crystal that is then collected and prepared for analysis. The crystal is positioned in the x-ray beam and diffracted x-rays are detected using an image plate detector. Data analysis and processing followed by modeling of the data yield the 3-dimensional structure. The 3-dimensional structure of the macro-molecule is used to study the details of the relationship between the structure of the biological macro-molecule and its function. Additionally, the 3-dimensional models of macromolecules are used in the intelligent design of pharmaceuticals and pesticides as well as to understand the nature of metabolic diseases.