NC State Biochemistry receives state and federal revenues, but these sources represent a fraction of the support required to maintain successful programs and facilities. Your donations will make the difference for our faculty and students to meet the global challenges of 21st Century:

- Enhancing the production, quality, accessibility and proftability of food, plant, animal and bioenergy products for North   Carolina, the nation and the world
- Ensuring environmental stewardship and sustainability of air, land, soil and water resources
- Creating a food supply that is safe, secure, healthy, affordable and of high quality
- Improving human health and well-being for individuals, families and communities and
- Preparing students and stakeholders for leadership and success in the global workforce.

NC State Biochemistry



E. Stuart Maxwell
Professor of Biochemistry

PhD, University of Massachusetts, Amherst
Postdoctoral, Insitute Jacque Monod, Paris; University of Chicago

Office: 332 Polk Hall
   Office: 919.515.5803
Email: E. Stuart Maxwell

E. Stuart Maxwell

Website: Visit our Lab Home Page

Research Areas: Synthesis, structure and function of the small nucleolar RNAs

The small nucleolar RNAs (snoRNAs) play crucial roles in ribosome biosynthesis. Using complementary sequences, the snoRNAs base pair with rRNA to guide the folding, site-specific nucleotide modification, and cleavage of precursor ribosomal RNA. Based upon conserved snoRNA sequence elements, this large population of guide RNAs has been divided into two major families designated the box C/D and the box H/ACA snoRNAs. The primary function of the box C/D snoRNAs is to guide 2'-O-methylation of targeted rRNA nucleotides while the box H/ACA snoRNAs direct the conversion of specific uridine residues to pseudouridine.

Our laboratory is investigating the biogenesis, structure, and function of the box C/D RNP nucleotide modification complexes using U14 as a model system for the eukaryotic snoRNPs. Early work from our laboratory reported the first intronic snoRNA and we subsequently demonstrated a novel pre-mRNA intron processing pathway for snoRNA biosynthesis. Our work then defined the terminal box C/D core motif, a folded RNA element essential for snoRNA processing, snoRNP assembly, and snoRNP transport to the nucleolus.