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NC State Biochemistry



Robert B. Rose
Associate Professor of Biochemistry

PhD, University of California, San Francisco
Postdoctoral, University of California, Berkeley

Office: 144 Polk Hall
   Office: 919.513.4191
Email: Robert B. Rose

Robert B. Rose

Website: Visit our Lab Home Page

Research Areas: Protein crystallography and function of transcription factors | Transcriptional regulation in pancreatic beta cells and diabetes

The capability to regulate gene expression in different cell types is fundamental to multi-cellular organisms. Mis-regulation of transcription contributes to many diseases, from diabetes to cancer. Our lab is interested in understanding how cell-specific transcription is regulated. Much of our work focuses on pancreatic beta cells as a model system. We are characterizing the mechanistic basis for cooperative interactions between transcription factors regulating expression of the insulin gene, and other beta cell-specific genes. In addition we are interested in coactivator interactions and protein modifications that modulate the activity of beta cell transcription factors. We are also studying how mutations in these transcription factors cause a familial form of diabetes, Maturity-onset diabetes of the young (MODY). Our work combines structural and functional approaches.