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NC State Biochemistry



Robert B. Rose
Associate Professor of Biochemistry

PhD, University of California, San Francisco
Postdoctoral, University of California, Berkeley

Office: 144 Polk Hall
   Office: 919.513.4191
Email: Robert B. Rose

Robert B. Rose

Website: Visit our Lab Home Page

Research Areas: Protein crystallography and function of transcription factors | Transcriptional regulation in pancreatic beta cells and diabetes

The capability to regulate gene expression in different cell types is fundamental to multi-cellular organisms. Mis-regulation of transcription contributes to many diseases, from diabetes to cancer. Our lab is interested in understanding how cell-specific transcription is regulated. Much of our work focuses on pancreatic beta cells as a model system. We are characterizing the mechanistic basis for cooperative interactions between transcription factors regulating expression of the insulin gene, and other beta cell-specific genes. In addition we are interested in coactivator interactions and protein modifications that modulate the activity of beta cell transcription factors. We are also studying how mutations in these transcription factors cause a familial form of diabetes, Maturity-onset diabetes of the young (MODY). Our work combines structural and functional approaches.

Most Recent Publications:

A High-Resolution Crystal Structure of a Psychrohalophilic α-Carbonic Anhydrase from Photobacterium profundum Reveals a Unique Dimer Interface.
PloS one
 11: e0168022 
Somalinga V | Buhrman G | Arun A | Rose RB | Grunden AM |

2017 Mar
Modeling the Growth of Archaeon Halobacterium halobium Affected by Temperature and Light.
Applied biochemistry and biotechnology
 181: 1080-1095 
Lu H | Yuan W | Cheng J | Rose RB | Classen JJ | Simmons OD |

2016 Mar
Evaluation of a DLA-79 allele associated with multiple immune-mediated diseases in dogs.
 68: 205-17 
Friedenberg SG | Buhrman G | Chdid L | Olby NJ | Olivry T | Guillaumin J | O'Toole T | Goggs R | Kennedy LJ | Rose RB | Meurs KM |

2015 Feb 13
Interactions with the bifunctional interface of the transcriptional coactivator DCoH1 are kinetically regulated.
The Journal of biological chemistry
 290: 4319-29 
Wang D | Coco MW | Rose RB |

2014 Jun 27
Carboxylation of cytosine (5caC) in the CG dinucleotide in the E-box motif (CGCAG|GTG) increases binding of the Tcf3|Ascl1 helix-loop-helix heterodimer 10-fold.
Biochemical and biophysical research communications
 449: 248-55 
Golla JP | Zhao J | Mann IK | Sayeed SK | Mandal A | Rose RB | Vinson C |