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NC State Biochemistry




Graduate Courses Offered by the Department of Molecular and Structural Biochemistry

Core Courses

BCH701: Macromolecular Structure

Offered Fall Semester

Introduction to the current understanding and methods used for the study of structures, thermodynamics and conformational dynamics of proteins, nucleic acids and membranes.

Instructors: Dr. Mike Goshe and Dr. Paul Wollenzien


BCH703: Macromolecular Synthesis and Regulation

Offered Fall Semester

Biochemistry of DNA replication, transcription, RNA processing and translation. Development of key concepts, techniques and applications relating to mechanisms and regulation of these processes by analysis of primary literature.

Instructors: Dr. Linda Hanley-Bowdoin and Dr. Paul Wollenzien


BCH705: Molecular Biology of the Cell

Offered Spring Semester

Regulation of cellular processes, membrane structure and function, signal transduction, protein trafficking/sorting. Instructors discuss protein processing within the cell and intracellular targeting as well as signal transduction as it relates to the regulation of cellular processes. Students will gain a fundamental knowledge in the structure:function relationships of protein signaling and translocation.

Instructors: Dr. Flora Meilleur and Dr. Mike Goshe


Advanced Graduate Courses

BCH761: Advanced Molecular Biology of the Cell

Offered Spring Semester, Alternating Years

An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions.

Instructor: Dr. Linda Hanley-Bowdoin


BCH768: Nucleic Acids Structure and Function

Offered Spring Semester, Alternating Years

An advanced discussion of RNA biology at the molecular level involving integrated approaches of biochemistry, cell biology, and molecular genetics. Class discussions will involve student presentations of the primary scientific literature to determine how broad, multidisciplinary approaches are used to solve research problems in RNA structure and function. An important component of this course is the development by each student of an original research proposal which is ultimately peer evaluated in a panel review format involving both both students and faculty.

Instructors: Dr. Stu Maxwell and Dr. Cindy Hemenway


BCH770: Enzyme Kinetics and Mechanisms

Offered Spring Semester, Alternating Even Years

An advanced course in enzyme kinetics and mechanisms with particular emphasis on experimental design and interpretation. The first half of the course covers the derivation and application of single and multisubstrate kinetic equations, inhibition and pre-steady state kinetics. The second half of the course covers fundamental chemical and physical principles of enzyme catalysis and specificity.

Instructors: Dr. Mike Goshe and Dr. Bob Rose


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